We suggest to take Brain Health (Voluntastrols) at night if you have had a head knock or concussion, or a history of them as they work with the glymphatic system in the brain that helps support inflammation and support optimal clearing of waste from brain. The glymphatic system is most active at night when you sleep. At times when needed, dosing twice a day (before breakfast and at bedtime) may be suggested for a period of time possibly 4-6 weeks.